IN the nucleic acids, cytosine is connected to a sugar residue through N 1 of the pyrimidine ring. Here we describe the results of an X-ray diffraction analysis of crystals of N 1-methyl cytosine.

Cytosine can undergo chemical modifications that play crucial roles in gene regulation and epigenetics. The most common modification is the addition of a methyl group to carbon 5, forming ...

Figure 1 | Proposed mechanism of DNA methylation and demethylation. A) Within the genome, the majority of CpG pairs are methylated by addition of –CH 3 to cytosine. B) DNA methylation involves ...

This 1:1 ratio of A:T and G:C is crucial for maintaining the structure and stability of DNA. 5-Methylcytosine is a modified nucleobase formed by the enzymatic addition of a methyl group to the 5th ...