We demonstrate that anaerobic glycolytic metabolism, while sufficient for embryonic stem cell homeostasis, must be transformed into the more efficient mitochondrial oxidative metabolism to secure ...

The identification of mitochondrial as well as of oxidative stress protein targets ... the inner membrane ANT-2, NADH dehydrogenase (ubiquinone) Fe-S protein 2 (OxPhos complex I), ubiquinol ...

Mitochondria are morphologically plastic organelles that cycle between ... Our previous work established TNBC cells that survive DNA-damaging chemotherapy (e.g., doxorubicin and carboplatin) are ...

This article explores the peptide's properties and highlights possible avenues of research where NAD+ might play a crucial role. We focus on areas such as cellular aging, neurodegeneration, circadian ...

This change was accompanied by lower levels of ATP and acetyl-CoA, but a higher NAD + /NADH ratio ... difference was more pronounced in mitochondria isolated from male mice (Area-Gomez et al., 2020).

"As a result, there is a higher oxidation of lipids in this specific population of mitochondria, a process that helps prevent ...

Retinal ganglion cells derived from individuals with glaucoma show an increase in oxidative stress and dysfunction of mitochondria ... NDI1 gene that encodes an NADH dehydrogenase, a protein ...

Our faculty in the Department of Chemistry are involved in cutting-edge research. They have authored and contributed to a number of publications—both in prior work and during their tenure at Michigan ...

Retinal ganglion cells derived from individuals with glaucoma show an increase in oxidative stress and dysfunction of mitochondria, the cell organelles involved in energy production. In this study, ...