In the past, Parkinson’s disease was primarily considered a disorder of the nervous system, centered in the brain. However, ...

The cellular and molecular mechanisms that maintain mucosal immune homeostasis are being defined. When these mechanisms fail, pathogenic effector T cells are generated that result in colitis. We have ...

Understanding the communication between mucosal sites is fundamental to the next phase of disease characterization and vaccine development. Appreciation of the mucosal immune system as a global ...

A better understanding of this crosstalk may help us to develop more effective mucosal vaccines, as well as new therapeutic and preventive measures against inflammatory diseases. At the juncture ...

[6] Four mucosal lesions of importance were identified ... The Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) was designed to evaluate the severity of inflammation, disease extent ...

For the study, researchers analyzed data from 9,350 people with no previous history of Parkinson’s disease. They discovered that those who had mucosal damage had a 76 percent greater risk of ...

Our ability both to assess disease activity and predict outcomes in IBD using available scoring methods is still developing. Both validation of existing methods as well as additional tools that ...

The Mucosal HIV and Immunobiology Center at the University of Alabama at Birmingham, established through the NIH's Digestive Diseases Research Development Center program, offers a unique opportunity ...

Parkinson’s disease may start in the gut, with gastrointestinal symptoms like constipation appearing years before ...

“Innovative therapeutics for autoimmune diseases of the intestinal mucosa have largely been dominated by injectable drugs. Our small molecule, OR-812, has the potential to offer IBD patients a ...