4) Another Mycobacterium virulence factor, CpsA, disrupts another degradation pathway and blocks the activity of NADPH oxidase, impairing the destruction of the bacteria. 5) By affecting the normal ...

Now ketamine, a glutamatergic NMDA receptor antagonist, may provide a mechanism that could link these pathways ... oxygen species and maybe even NADPH oxidase.

Scientists are looking at a range of different drug classes, such as lysyl oxidase (LOX) inhibitors and NADPH-oxidase inhibitors ... cellular signalling pathways that lead to a build up ...