It has, therefore, been suggested that selective COX-2 inhibitors of the inducible isoform may be free from renal adverse effects. Recent evidence suggests that this may not be so. Samir Malhotra ...

COX-2 levels increase during developmental synaptic remodeling 5 and upregulation of synaptic activity 6. Moreover, COX-2 is involved in the coupling of synaptic plasticity with cerebral blood flow 7.

"Very lame and imperfect theories are sufficient to suggest useful experiments which serve to correct those theories and give birth to others more perfect. These, then occasion farther experiments ...