The dual-action agent LCZ696 blocks the angiotensin II receptor (via a valsartan moiety) and inhibits neprilysin (via an AHU377 moiety). In a phase II trial, this drug “demonstrated superior ...

In patients with heart failure (HF) due to acute myocardial infarction (AMI), angiotensin receptor–neprilysin (ARN) inhibitors lower the risk for cardiovascular (CV) events, reduce HF ...

History of ACEI-associated or other angioedema. Anuria. Sulfonamide allergy. Concomitant neprilysin inhibitors (eg, sacubitril); do not administer benazepril/HCT within 36hrs of switching to or ...