Selectivity of NSAIDs is currently based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/ or COX-2). IC 50 values provide no indication of the ...

NSAIDs are the principal agents used for managing pain in patients with chronically painful diseases, such as osteoarthritis. However, the withdrawal of the selective cyclo-oxygenase 2 (COX2 ...