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16 天
Cell | 从氧化应激到癌症:BACH1如何平衡生与死?
在正常条件下,BACH1占据主导地位,通过抑制与氧化还原平衡相关基因的表达来维持静息状态。然而,当氧化应激发生时,NRF2被释放并转移到细胞核中,迅速启动抗氧化基因的表达,如血红素加氧酶-1(heme oxygenase-1, ...
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