p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

[23,25,26] The pivotal role of MDM2 and MDM4 in the control of p53 function argues that polymorphisms at these loci should be scrutinized for potential modulation of p53 function. The range of ...

P47S, a rare polymorphism in the N-terminal transactivation domain of p53, results from a C>T base substitution at position 1 of codon 47. It has only been reported in populations of African ...

However, p53 can mutate and is then no longer able to entirely fulfill its actual function: Cell growth is no longer delayed, there is no time for repairs and cell death is not initiated.

Researchers in Michael Sigals lab at the Max Delbruck Center and Charite - Universitatsmedizin Berlin have discovered the ...

The human body contains proteins that are designed to protect us from cancerous growths. Like most proteins, to do their job properly, these “guardians” have to fold into a specific three-dimensional ...

Through studies of proteins that regulate p53, scientists at St ... Kriwacki's investigations into p14 ARF function began ...