引言癌症背后的分子机制一直是科学研究的热点。在癌症的众多驱动因素中，TP53基因被誉为“基因组的守护者”，是人类体内最重要的肿瘤抑制基因之一。然而，这位“守护者”也常常成为癌症发展的“叛徒”，数据显示，大约50%的癌症患者都携带TP53基因的突变。这 ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...

However, p53 can mutate and is then no longer able to entirely fulfill its actual function: Cell growth is no longer delayed, there is no time for repairs and cell death is not initiated.

Through studies of proteins that regulate p53, scientists at St ... Kriwacki's investigations into p14 ARF function began ...