引言癌症背后的分子机制一直是科学研究的热点。在癌症的众多驱动因素中，TP53基因被誉为“基因组的守护者”，是人类体内最重要的肿瘤抑制基因之一。然而，这位“守护者”也常常成为癌症发展的“叛徒”，数据显示，大约50%的癌症患者都携带TP53基因的突变。这 ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

After receiving this validation, we developed panels of guide RNAs for generating targeted mutations in the p53 tumour-suppressor gene. More than half of all cancers have mutations in p53 that ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfill its task. Until now, researchers have assumed that the process is the same with all mutation types.

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

Comparison between the response of tumoral cells to chemotherapy with no mutation of p53 (upper cells) and of mutation of p53 (lower cells). Disclaimer: AAAS and EurekAlert! are not responsible ...

Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

p53 is often referred to as the “guardian of the genome” due to its critical role in maintaining genomic stability, but it can be altered in cancer with mutations such as Y220C. The Y220C ...