p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

A naturally occurring p53 isoform, called Δ40p53 (or ΔNp53), causes accelerated aging in mice when expressed together with WTp53. We generated genome-edited human cell lines that express Δ40p53:WTp53 ...

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.