In women with ovarian cancer, the p53 mRNAs are just as defective as the gene from which they were copied. "We produced an mRNA in the laboratory that contained the blueprint for a normal ...

"We produced an mRNA in the laboratory that contained the blueprint for a normal, non-mutated p53 protein," stated Dr. Monika Raab from the Department of Molecular Gynecology and Obstetrics.

In a cross-sectional study of 302 individuals (205 women, 97 men; BMI: 16.9-85.5 kg/m², age: 16-90 years), FAS and p53 mRNA expression were assessed in subcutaneous and visceral WAT collected ...

It turned out that the increase in the expression of the p53 protein was caused by the stabilization ... which allow a smaller amount of mRNA samples to be analysed. One of the greatest advantages ...