We also found that tumor growth induces overly activated regulatory T (Treg) cells with their CTL suppressor function titratable along the PI3K-Akt-Foxo1 signaling pathway to overcome cancer immune ...

Gedatolisib is under clinical development by Celcuity and currently in Phase I for Endometrial Cancer. According to GlobalData, Phase I drugs for Endometrial Cancer have an 81% phase transition ...

Non-transformed cells depend on growth factor signaling to direct glucose and glutamine uptake. These observations led us to hypothesize that there might be specific oncogenic transformation events ...

The results showed that cordycepin significantly inhibited growth factor signaling in multiple cell lines, particularly through the MEK/ERK and PI3K/AKT/mTOR pathways. This inhibition was observed ...