The study's primary goal is to assess the therapy’s tolerability, pharmacokinetics and safety in healthy volunteers.

A new study reports that mirodenafil, a newly developed oral phosphodiesterase type 5 (PDE5) inhibitor, is an efficacious and safe treatment for erectile dysfunction (ED). Many men with ED ...

Like other prescription medicines, Viagra and its generic form, sildenafil, work best when you take them under the right ...

The cyclic nucleotide phosphodiesterase 4 (PDE4 ... However, none of the PDE4 inhibitors tested so far has reached the market, mainly owing to tolerability issues such as emesis.

Objective: To review available literature evaluating the pharmacology, pharmacokinetics, clinical efficacy, and adverse effects of cilomilast, a selective phosphodiesterase-4 (PDE4) inhibitor.

Topical antifungals, although often effective, are being discouraged in the early treatment of seborrheic dermatitis now that ...

The introduction of phosphodiesterase-5 inhibitors (PDE5Is) in the market, such as generic Levitra, has revolutionized the ...

Funded by the National Institute on Drug Abuse, Omeros’ lead phosphodiesterase 7 inhibitor OMS527 is in clinical development for the treatment of cocaine use disorder. Omeros also is advancing a ...

Additional studies showed a role for the Cgs2 phosphodiesterase that hydrolyzes cAMP to AMP ... We have completed HTSs for PDE4, PDE7, PDE8, and PDE11 inhibitors. The compounds identified in these ...

Sildenafil is an ingredient known as a Phosphodiesterase Inhibitor (PDE-5) found in FDA- approved products for the treatment of male erectile dysfunction. According to the FDA, consumption of ...