These bonds are called phosphodiester bonds, and the sugar-phosphate backbone is described as extending, or growing, in the 5' to 3' direction when the molecule is synthesized. In double-stranded ...

This step occurs by transesterification; in this case, an OH group at the 3′ end of the exon attacks the phosphodiester bond at the 3′ splice site. The adjoining exons are covalently bound ...

TComparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases (Image: Wikimedia Commons, CC SA 3.0) The nucleotides are connected through phosphodiester bonds, ...

My scientific interests center on nucleases, a functionally diverse class of enzymes that catalyze the cleavage of phosphodiester bonds to support a wide breadth of pathways, including DNA replication ...