Alternative splicing increases protein diversity by allowing multiple, sometimes functionally distinct, proteins to be encoded by the same gene. It can be specific to tissues, stress conditions ...

Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

A new study helps explain the role of genetic variation in shaping gene regulation in the Indonesian archipelago, one of the most diverse regions in the world. “This study is the only study of ...

Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

Proteoforms are different forms of a protein encoded by a single gene. These variants can arise from post-transcriptional ...

The shrew's resting heart rate can reach up to 17 beats per second, equivalent to about 1,020 beats per minute. In comparison ...

Researchers in the U.K. have succeeded in reverse engineering the defective cryptic splicing that drives amyotrophic lateral ...