GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of purine nucleotides in cells. Disorders of purine metabolism can lead to ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP)-;the ...

Early life stress (ELS) can have long-lasting effects on mental health, increasing the risk of developing anxiety disorders ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

They soon discovered, from observing the role of purines in nucleic acid metabolism, that bacterial cells require certain purines to make DNA. Hitchings hypothesized that by preventing those purines ...