SR proteins act at several steps during normal and alternative splicing — they work by binding to sequences called exonic splicing enhancers (ESEs) through their RNA-binding domains and ...

Specific RNA Sequences ... and alternative-splicing sequences. Additional sequences are designated as splicing enhancers or silencers, and serine-arginine rich (SR) proteins bind these sequences ...

This study provides important insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...

"So, we hypothesized maybe the splicing factors have another function, like a dual function." The protein that stood out was the RNA-binding protein RBM5. The researchers found that RBM5 is highly ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...