The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

Sigma-2 receptor modulation using exogenous ligands reduces cellular damage associated with central nervous system degeneration in age-related pathologies such as Alzheimer’s disease, Parkinson’s ...

More information: Jiuyin Xu et al, Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.

Targretin (LGD1069), a high-affinity ligand for the retinoid X receptors (RXRa, RXRb and RXRg), is highly effective in the prevention and treatment of carcinogen-induced breast cancer in various ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in ...

A new protein antagonist design strategy shows promise against leukaemia by targeting important receptors to stop the proliferation of cancer cells. A new family of protein-based antagonists has been ...

Alon Kahana, MD, PhD, discusses the role of interleukin-6 in thyroid eye disease and the potential of tourmaline Bio's IL-6 ...