The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

In contrast, TLRs 3, 7, 8, and 9 are situated in the membranes of endosomes and lysosomes; the extracellular domain of the receptor and its ligand-binding site project into the interior of these ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

More information: Jiuyin Xu et al, Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.

GPR6 is an orphan G protein-coupled receptor primarily expressed in the ... revealed a lipid-like molecule occupying the orthosteric ligand-binding pocket. A cryo-EM structure of the fully active ...

Sigma-2 receptor modulation using exogenous ligands reduces cellular damage associated with central nervous system degeneration in age-related pathologies such as Alzheimer’s disease, Parkinson’s ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in ...

These receptors are involved in many processes ... The common understanding of how to activate an aGPCR is that a ligand from outside the cell attaches to one of the extracellular domains and ...

Alon Kahana, MD, PhD, discusses the role of interleukin-6 in thyroid eye disease and the potential of tourmaline Bio's IL-6 ...