If primary cilia can act as one type of receptor ... Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Nature Reviews Genetics 6, 928-940 (2005) doi:10.1038/nrg1727.

which constitute the major cilium-containing cell type in the kidney, expressed PD-L1 at the highest level. Loss of IFT88 in mRTECs (an immortalized murine cell line of RTECs) disrupted primary ...

UAB's Bradley Yoder has helped connect primary cilia with a host of human ailments, from kidney disease to obesity and even cancer. At top, primary cilia (colored green and red) protrude from renal ...

Her lab studies animals like roundworms, zebrafish and mice to ascertain how the primary cilia may cause CHD. Her current focus is to study two genes Nphp4 and Bbs5 that are affected in CHD. These ...

often lost in renal cell carcinoma, outside their traditional habitat of chromatin in the nucleus. We are investigating the function of these epigenetic modifiers on microtubule and actin dynamics ...

Dysfunctions of the tiny cell processes (primary cilia) of the pancreatic beta cells could be a cause of type 2 diabetes.

Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems and play a role in BCC. The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC ...

Primary cilia have emerged as key organelles in Hh signal transduction in mammalian systems and play a role in BCC. The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC ...