Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

This indicates that ATM functions upstream of p53 in the IR-induced signal transduction ... or other domains of ATM may have important roles in these pathological conditions.

For example, MDM2 binds to TP53 mRNA, controlling the rate of translation, [24] and MDM2 regulates the levels of itself, MDM4 and p53. [23,25,26] The pivotal role of MDM2 and MDM4 in the control ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease. This unexpected discovery could help doctors identify which ...

Scientists from the Barts Cancer Institute and the Francis Crick Institute have demonstrated that a genetic flaw that has ...

a group of researchers investigated the role of Fas Cell Surface Death Receptor (FAS) in regulating Tumor Protein p53 (p53) expression in adipocytes and its impact on energy metabolism ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

p53 is often referred to as the “guardian of the genome” due to its critical role in maintaining genomic stability, but it can be altered in cancer with mutations such as Y220C. The Y220C ...