Spindle fibers form a protein structure that divides the genetic material in a cell. The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during ...

In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a cellular machine composed of microtubules and their associated proteins. Spindles are built from ...

A large structure called the mitotic spindle also forms from long proteins called microtubules on each side, or pole, of the cell. During prometaphase, the nuclear envelope that encloses the ...

Motor motion on cytoskeletal filaments is particularly important for biological length regulation, because numerous proteins targeted to microtubule ends modify their dynamics and can dramatically ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

SB-715992 is a new agent that inhibits the function of a mitotic kinesin known as kinesin spindle protein and leads to cell death. Patients and Methods: Twenty patients with previously treated ...