It is now clear that regulation of alternative splicing has a huge impact on gene function and there is a great deal to learn about questions ranging from the mechanisms of coordinated alternative ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team. The process known as splicing causes the cell's protein-making ...

In the current study, the investigators aimed to identify the alternative splicing changes in glioma tumor cells, the mechanisms underlying these alternations, and determine their potential as ...

tRNA splicing occurs in two stages: (i) intron excision and (ii ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of fungal/plant tRNA ligase; (ii) developing a ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

This important study reveals a new mechanism for gene regulation in neurons by an RNA binding protein called RBM20 previously studied in the heart. The methods used are compelling, including the ...