Massagué has been lauded for the originality and importance of his work elucidating the mechanism of action for transforming growth factor-beta (TGF-β) signaling. The TGF-β family of proteins plays a ...

This loss could include chronic injury or aging. The cells responsible for repair are mainly fibroblasts, and the molecular basis for their responses includes signaling through the cytokines TGF-β and ...

Aberrant TGF-β signaling and EMT are implicated in renal fibrosis ... and immune-mediated pruning of cancer cells in lung cancer metastasis as revealed by sngle-cell analysis (from Laughney et al ...

Sai Wang and several collaborators, how ECM1 acts as a "gatekeeper" in a healthy liver to suppress the activation of the signaling molecule transforming growth factor-β (TGF-β). TGF-β plays a ...

Diabetes researchers and bioinformaticians from the Icahn School of Medicine at Mount Sinai have developed a new ...

For more than 15 years, researchers at the Icahn School of Medicine at Mount Sinai have worked tirelessly to find a solution ...