Massagué has been lauded for the originality and importance of his work elucidating the mechanism of action for transforming growth factor-beta (TGF-β) signaling. The TGF-β family of proteins plays a ...

如今研究人员距离再生医学转化为实际疗法又更近了一步，相关研究在利用患者自身的细胞来修复机体心脏损伤上又迈出了重要的一步。直接进行心脏重编程是一种能绕过中间 干细胞 ...

Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

This mechanism regulates proteostasis across tissues by modulating TGF-β signaling, a pathway involved in cell growth, differentiation, and tissue homeostasis. This breakthrough opens exciting ...

Aberrant TGF-β signaling and EMT are implicated in renal fibrosis ... and immune-mediated pruning of cancer cells in lung cancer metastasis as revealed by sngle-cell analysis (from Laughney et al ...

A groundbreaking review highlights significant advancements in the understanding and treatment of cerebral vascular ...

More information: Gan Zhao et al, TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue, Science Translational Medicine (2024). DOI: 10.1126 ...

Diabetes researchers and bioinformaticians from the Icahn School of Medicine at Mount Sinai ... that DYRK1A inhibitors can synergize with TGF-beta signaling as well as GLP-1 receptor agonist ...

For distinguished contributions to the field of cancer biology, particularly in TGF-beta signaling, and for tireless mentorship and service. The new fellows will receive official recognition during ...