The focus of this proposal is to investigate the extent of structural plasticity in the recognition of these flexible ligands. We use the recognition of ssDNA by the telomere end-binding proteins as ...

The G-richness and highly repetitive nature of telomeric DNA pose major challenges to the DNA replication machinery. In the lab, we recently highlighted a role for the telomere binding protein, POT1, ...

In the absence of ZBTB48 (right panel) telomeres become longer whereas the expression of ZBTB48 target genes is strongly reduced. For instance, ZBTB48 KO (knock-out) cells loose the expression of ...

MCD1 and MCD2 look like a DNA binding domain ... To connect the protein complexes to the telomeres, MCD3 binds to the ...

Telomir Pharmaceuticals (NASDAQ: TELO) announced promising preclinical findings demonstrating the copper-binding capabilities of its Telomir-1 drug ...