We now appreciate that this unusual complex of DNA and protein is a dynamic structure that depends on telomerase and other cellular factors for maintenance. Regulation of telomere function is an ...
In the absence of ZBTB48 (right panel) telomeres become longer whereas the expression of ZBTB48 target genes is strongly reduced. For instance, ZBTB48 KO (knock-out) cells loose the expression of ...
In the lab, we recently highlighted a role for the telomere binding protein, POT1, in assisting the replisome when copying telomere repeats (Pinzaru et al., Cell Reports 2016). Notably, mutations in ...
We use the recognition of ssDNA by the telomere end-binding proteins as the predominant model to characterize the contribution of structural plasticity to recognition. The telomere-end binding ...
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What Are Telomeres ? Can They Slow Down Ageing?Telomeres are structures made of repetitive DNA and protein, safeguarding our genetic material during cell division. Over ...
MCD1 and MCD2 look like a DNA binding domain ... To connect the protein complexes to the telomeres, MCD3 binds to the ...
Surprisingly, this family has been robustly identified as novel RNA-binding proteins in numerous crosslinking studies. Subsequent validation of these interactions and the additional observation that ...
Telomir Pharmaceuticals (NASDAQ: TELO) announced promising preclinical findings demonstrating the copper-binding capabilities of its Telomir-1 drug ...
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