Thiazolidinediones (TZDs ... but without the associated toxicity. The precise mechanism of action of TZDs is still under investigation. However, much of their antidiabetic action is thought ...

Thiazolidinediones activate peroxisome proliferative activated receptor γ, which increases insulin sensitivity and makes these agents an effective treatment for diabetes. Animal studies have ...

Purpose: A review of the significant findings related to the use of the thiazolidinediones (TZDs) in the treatment of patients with type 2 diabetes mellitus and heart failure was conducted.

The thiazolidinediones (rosiglitazone and pioglitazone) lower blood sugar levels among individuals with type II diabetes. The thiazolidinediones have favourable effects on surrogate markers of ...