Thiazolidinediones (TZDs ... but without the associated toxicity. The precise mechanism of action of TZDs is still under investigation. However, much of their antidiabetic action is thought ...

Thiazolidinediones activate peroxisome proliferative activated receptor γ, which increases insulin sensitivity and makes these agents an effective treatment for diabetes. Animal studies have ...

Purpose: A review of the significant findings related to the use of the thiazolidinediones (TZDs) in the treatment of patients with type 2 diabetes mellitus and heart failure was conducted.

Oral antidiabetic medications can be separated by mechanism of action into two groups ... The α-glucosidase inhibitors and thiazolidinediones pose minimal risk of adverse events in acute overdose.