This ongoing study uses minimal residual disease analysis at two follow-up points, to facilitate risk-adapted treatment stratification in ALL patients aged 1–18 years. In the current analysis ...

Thiopurine metabolism and thiopurine methyl transferase (TPMT) enzyme activity assay. Azathioprine (AZA) is converted into 6-mercaptopurine (6-MP), which can also be administered as a parent drug.

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...