as essential to the suppressive function of regulatory T cells (Tregs) in the tumor microenvironment (TME). This discovery ...

These four studies help resolve contradictory reports of differing mechanisms governing Treg differentiation and suppressive functions 1 and suggest novel therapeutic approaches. Clinical trials ...

These TREG cells impede the function of the effectors in combating the tumor. The chemokine CCL22, produced by the tumor cells, binds to its receptor (CCR4) on the TREG cells and mediates their ...