Lack of NaV1.7 activity leads to the inability to sense pain, whereas NaV1.7 gain of function leads to severe pain. Modulation of NaV1.7, therefore, should be an effective mechanism for decreasing ...

A subset of arthritis patients suffer from neuropathic pain arising from damage to joint nerves. Some of the main targets of these injured nerves are the voltage gated sodium channels NaV1.7 and ...

Competing Interests: The author declared no competing interests. Voltage-gated sodium channels can contribute to axonal injury in multiple sclerosis (MS) by providing a pathway for sustained ...