XORTX to focus on late stage allopurinol intolerant gout program; discussion with FDA planned for first half 2025 regarding ...

For gout, xanthine oxidase (XO) inhibitors are the choice for first ... which showed that the drug’s effect on decreasing plasma uric acid dropped off significantly with lower creatinine clearance.

These results led to the discovery of novel compounds such as tubulin and xanthine oxidase inhibitors. Further to reveal their mechanisms to act as potent ... as well as a keen understanding of what ...

The current strategy for managing chronic gout is the use of uric-acid-lowering drugs to reduce urate ... underexcretion of uric acid. [23] Xanthine oxidase inhibitors block uric acid production ...

Allopurinol is a xanthine oxidase inhibitor, recommended for treating the increased uric acid levels caused by cancer drugs.

Allopurinol is a xanthine oxidase inhibitor, recommended for treating the increased uric acid levels caused by cancer drugs.