研究人员发现心肌注射hCVPCs在改善小鼠梗死心脏心功能和减少纤维疤痕的同时，可以诱导心肌细胞去分化并重新进入细胞周期。此外，已经失去增殖能力的成年大鼠心肌细胞经hCVPCs条件性培养基培养后也发生了去分化和细胞增殖，表明hCVPCs的分泌物激活了成 ...

【导读】阿霉素诱导的心肌病的发病机制，尚不清楚。这项研究是为了验证团队的假设，即ADAM17加重阿霉素诱导的心肌细胞凋亡，抑制ADAM17可能改善阿霉素诱导的心肌病。2024年10月16日，山东大学齐鲁医院张运院士团队在期刊《Signal ...

BACKGROUND: Many specialized cells in adult organs acquire a state of cell cycle arrest and quiescence through unknown ...

More information: Ryu Matsumoto et al, CD8+ T cell-mediated rejection of allogenic human-induced pluripotent stem ...

These complications are caused by intrinsic defects in cardiomyocyte and cardiac conduction system function, and by the presence of severe skeletal muscle disease, which also contributes to ...

The intensive investigations utilizing single-cell genomics and genetic experiments were conducted by a team of scientists in the Cardiomyocyte Renewal Laboratory and McGill Gene Editing Laboratory at ...

In addition, the researchers used induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) cell cultures as a model to study how genes are expressed during heart development in humans and ...

Direct cardiac reprogramming is a new technology which converts a somatic non-myocyte directly into an induced cardiomyocyte (iCM). This technology not only provides a promising platform for the study ...

Hemostemix Inc. (TSXV: HEM) (OTC Pink: HMTXF) (FSE: 2VF0) is pleased to announce that the Company is closing up to $4,000,000 ...

An established cardiac myosin inhibitor for hypertrophic cardiomyopathy (HCM), mavacamten (Camzyos) showed potential for reducing myocardial wall stress and cardiomyocyte injury in 30 HFpEF ...