【导读】SLC7A9负责二元氨基酸和胱氨酸（内流）与中性氨基酸（外排）的交换。胱氨酸/半胱氨酸转运与铁死亡有关。2024年10月21日，上海交通大学医学院附属瑞金医院刘炳亚团队在期刊《eBioMedicine》上发表了题为“SLC7A9 ...

【导读】转录辅因子退化样3（VGLL3）作为女性偏倚自身免疫的主要调节因子，也在肿瘤发展中发挥作用，而潜在机制在很大程度上仍然难以捉摸。在这项研究中，团队报道了VGLL3在DNA损伤反应（DDR）中起重要作用。2024年10月9日，中国科学院北京基因 ...

Restoration of chemosensitivity in chemoresistant myeloma cells allows rechallenge of previously unsuccessful therapeutic agents, which might allow further disease control in patients with ...

2024年2月，北京协和医院呼吸与危重症医学科肖毅教授团队在发表于杂志“Sleep Medicine”上的文章“The potential interaction between chemosensitivity and the ...

上在线发表了题为VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair的研究论文。该研究发现了VGLL3的转录非依赖功能，揭示了VGLL3通过N ...

DNA双链断裂是严重的DNA损伤类型。若不能及时准确修复DNA双链断裂，细胞基因组将面临染色体片段缺失、易位等问题，甚至导致细胞死亡。细胞主要依赖非同源末端连接和同源重组途径修复DNA双链断裂。相比于高效但易出错的非同源末端连接，同源重组是更精准的修复机制。而同源重组依赖于同源染色体的正确信息来修复断裂。

A research group led by Prof. Guo Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and ...

A research group led by Prof. GUO Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and TANG Tie-Shan from the ...

Background: The pathogenesis of daytime hypercapnia (PaCO 2 ≥ 45 mm Hg) may be directly linked to the existence of obstructive sleep apnea syndrome (OSAS) per se, although only some patients ...

The Chinese Academy of Sciences (CAS) (simplified Chinese: 中国科学院; traditional Chinese: 中國科學院; pinyin: Zhōngguó Kēxuéyuàn), formerly known as Academia Sinica, is the ...

Herein, we aimed to investigate the efficacy of BRT in enhancing chemosensitivity to Gem and to elucidate the underlying ...