In contrast to this approach, Fu et al. developed a model that is trained directly on chromatin-accessibility data from diverse cell types (Fig. 1). In this way, a single unified model can learn ...

The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

New research from the Center for Physical Genomics and Engineering uncovers how 3D genome structures generate cellular memories, paving the way for advances in medicine and longevity through cellular ...

In eukaryotes, genomic DNA is stored in the nucleus as nucleosomes, interacting with a set of proteins, forming a molecular complex called chromatin. The proper folding of the chromatin structure ...

DNA has to be carefully packaged and organized in cells so it will both physically fit into the nucleus, but will also remain ...

In a groundbreaking study, scientists have discovered a way to manipulate the very fabric of life by using light to reshape ...

Although epigenetic phenomena have been observed for over a century, researchers have only started to untangle their underlying mechanism and effects on gene expression. This course provides and ...

We specialize in high throughput top down liquid chromatography-mass spectrometry. This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to ...

The retina is a dynamic tissue of the eye made up of many different types of cells. Scientists at St. Jude Children's ...

JERUSALEM, Jan. 7, 2025 /PRNewswire/ -- Senseera, a liquid biopsy company pioneering chromatin epigenomics, announced the successful close of a $7.1 million seed funding round led by Lightspeed ...