The simplest version of a drop-off assay includes two TaqMan™ probes targeting the same amplicon: a drop-off probe that spans the mutation hotspot but is uniquely complementary to the wild-type ...
In August, the FDA approved Rybrevant in combination with oral EGFR-TKI inhibitor ... metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R substitution mutations. The FDA approval was ...