Children with MMA and PA suffer from repeated metabolic crises because their cells are missing one enzyme. What we’re trying to do is use mRNA to provide the missing information, so that ...

Imagine you're a scientist, tasked with the challenge of rapidly producing large quantities of high-quality messenger RNA (mRNA) for use in cutting-edge medical treatments. Where do you even start?

We have evaluated a well-characterised herbal extract for its ability to affect the mRNA expression profile ... Two transcripts for antioxidant enzymes were up-regulated (>threefold at 6 hours).

Enzymes called RNA polymerases transcribe DNA into RNA ... RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main type of RNA that gets translated into ...

The N-terminal ATP-dependent ligase domain belongs to the covalent nucleotidyltransferase enzyme superfamily that includes classic RNA/DNA ligases and mRNA capping enzymes. We’ve shown that: (i) each ...

A new way forward The way so many RNA viruses thrive is by modifying their RNA caps, specialized structures that stabilize viral RNA, enhance its translation, and mimic host mRNA to evade immune ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).

Expert Rev Vaccines. 2012;11(1):55-67. A summary of the events taking place after intradermal injection of naked mRNA is given inFigure 1. Although formulation of mRNA vaccines and sophisticated ...

A study published in PNAS reveals how a bacterial pathogen coordinates N-acetylneuraminic acid (Neu5Ac) metabolism at the ...

A study reveals how Salmonella enterica leverages a small RNA, ManS, to regulate Neu5Ac metabolism and adapt to the host ...