Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

What’s the secret behind calorie restriction’s health benefits? Meet LCA, a powerful molecule improving energy, muscle health ...

Aging involves gradual functional decline across various biological systems, including impaired cellular mechanisms such as ...

This study investigates miR-200a-5p’s role in the AMPK/SERCA2b pathway to reduce liver fat accumulation and ER stress in MASLD. Methods: A PA cell model induced by palmitic and oleic acids (2:1) was ...

Weight loss is a complex process as there are several angles that need to be addressed Some supplement providers emphasize the importance of strengthening liver function for healthy metabolism while o ...

PERK signaling can activate the signaling of TXNIP ... In mouse lungs, it mitigates cigarette smoke-induced emphysematous COPD pathologies through the AMPK pathway, concurrently suppressing the ...

12月18日Nature的研究报道“Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing”，聚焦于LCA通过溶酶体信号通路（lysosomal signaling pathway ...

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Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China ...

That led them to conduct a second study to learn more about how LCA activates AMPK. They found that activation was dependent on signaling from certain members of the enzyme family called sirtuins.