In this study we show, that ursodeoxycholic acid (UDCA), a bacterial metabolite, has cytostatic properties in pancreatic adenocarcinoma cell (PDAC) models. UDCA in concentrations corresponding to the ...

During hepatocellular carcinoma (HCC) development, cancer cells generally exhibit increased cell proliferation due to mutations or aberrant expression of key regulatory genes. The current study ...

Correlative data is provided to support the possible establishment of an immunosuppressive microenvironment near SCL26A3+ cells, and an association of these cells with upstaging at time of surgery.

A multiplex drug screening platform with cellular biosensors identifies antivirals against 40 diverse viruses simultaneously.

With the advent of these technologies and approaches, the field has grown, in just a few years, from profiling pancreas disease states to identifying molecular mechanisms of therapy resistance in ...

The matrix is a dense structure that supports organs and tissues ... identified by high-content screening modulate invasive carcinoma cell migration, PLOS Biology (2024). DOI: 10.1371/journal.pbio.

A T cell, for instance, has a lock-shaped structure on its surface into which a corresponding structure on the cancer cell's surface fits like a key. In technical terms, the lock of the T cell is ...

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt ...

1Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

and was described as “Ehrlich's mouse carcinoma.” It is one of the most rapidly, if not the most rapidly, growing of transplantable tumours, and on inoculation into mice takes in 100 per cent.