Toronto Western Hospital, The University Health Network (UHN), 60 Leonard Avenue, Toronto, Ontario, Canada M5T 2S8; mkapoor{at}uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a ...

P2X7 Inhibits mTOR Phosphorylation and Modulates M2 Markers in SOD1-G93A Microglia Inhibition of mTOR pathway is generally required for the induction of conventional autophagy (Klionsky et al., 2016).

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, a catabolic process induced under stress conditions, has been shown to play a dual ...

Design Gain- and loss-of-function assays were performed to evaluate the effects of miR-541 on the malignant properties and autophagy of human HCC cells. Autophagy was quantified by western blotting of ...

What are the best Western games on PC? It’s not an easy decision to make. The Wild West was a time of lawlessness, striking gold, and perilous shootouts – no wonder it’s the subject of many ...

After a decades-long cease-fire crumbled in 2020, Morocco and the pro-independence Polisario Front have resumed fighting over the disputed Western Sahara. Tensions are again rising over Western ...

Both television and cinematic content of the ever-evolving Western genre have found their place in the digital library of Netflix, which houses some of the most compelling TV shows in the genre. This ...

Here, a degree is a pursuit of purpose where learning empowers you, well-being strengthens you and an experience-driven education leads to a meaningful career. Western is the place to become your best ...