Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical ...
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This inhibits osteoclast-mediated bone destruction. One of Amgen’s top-selling drugs, Xgeva brought in revenues approaching $390 million in Q3 alone, while Prolia generated sales of $464 million.