胰腺癌的化疗耐药性是治疗失败的主要原因之一。近日，斯坦福大学研究人员在Nature Materials（影响因子IF=37.2）上发表重磅研究论文 [1]，阐明其利用患者来源肿瘤类器官技术，通过构建不同硬度的工程化基质，发现胰腺癌耐药性机制的关键原因 ...

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

Correspondence to Dr Zhiqi Zhang, Department of Joint Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510080, China; zhzhiqi{at}mail.sysu.edu.cn; Dr Weiming Liao; ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

(A) CD34 stained cells and LMC staining with SMA (B) and calponin (C) and the corresponding merged (D) image. Significant overlap in (E) CD34 staining along with the fibroblast marker PDGFRα compared ...

Myeong-Hwa Song. The team has unveiled an innovative technique to convert fibroblasts—common connective tissue cells—into mature and functional induced cardiomyocytes (iCMs). Their method ...

The pelviperineal organs of the female reproductive tract form an essential cornerstone of human procreation. The system comprises the ectodermal external genitalia, the Müllerian upper-vaginal, ...

1 Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China 2 Beijing Key Laboratory of Diabetes Research and Care, Beijing, China ...

This manuscript offers valuable insights by identifying two distinct liver cancer subtypes through multi-omics integration and developing a robust prognostic model, validated across various datasets, ...