Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...

Hematopoietic deficiency of CCL3 reduced atherosclerotic lesion size, without changing plaque macrophage, collagen, and SMC content. Of note, neutrophil adhesion to, and accumulation in, the lesions ...

Therefore, m6A regulators are essential for the regulation of tumor immune effects. Macrophages are essential regulators of the immune system and include classically activated macrophages (M1) and ...

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) constitutes a critical therapeutic approach for patients with malignant hematological disorders. Nevertheless, acute graft-versus-host ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...