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药物代谢酶CYP450代谢表型研究体外评估模型解析
这适用于CYP酶和非CYP酶。于前者而言,最常研究的是CYP1A2、CYP2B6、CYP2C8、CYP2C9、CYP2C19、CYP2D6和CYP3A4这7种酶亚型。 多种源自人体肝脏的体外系统可用于考察药物潜在的药物相互作用。 亚细胞的人肝组织组分,如微粒体系统,肝组织匀浆 9000 g离心后的上清液(S9 ...
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