In plants, transcriptional activation of the WEE1 gene (which encodes the CDC25-counteracting WEE1 kinase) represents the prevailing pathway that arrests the cell cycle under conditions that cause ...

Odyssey Therapeutics Inc. has synthesized CDK2/cyclin E1 inhibitors reported to be useful for the treatment of cancer.

State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ...

Kinases have a pivotal role in phosphorylation and kinase dysregulation has been implicated in the occurrence and progression of various diseases. By mid-2024 the Food and Drug Administration had ...

Bakuchiol inhibited DNA replication and activated the checkpoint kinase CHK1 by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand break (DSB) repair by inhibiting the ...

Emotional dependence involves relying on your partner to meet the majority or all of your needs. When you experience distress, you might look to them immediately before trying to manage your ...

1Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate ...

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil ...