she noticed that cells do not tolerate the presence of unprotected chromosome ends, and that broken ends are quickly fused together by the DNA repair machinery. McClintock also saw that telomeres ...

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...

In cells from these mice, telomeres shortened rapidly, but cells did not go through senescence. Instead, most cells reached the chromosome crisis stage, at which point most underwent apoptosis.

Telomeres are structures made of repetitive DNA and protein, safeguarding our genetic material during cell division. Over ...

W. Szostak and Carol W. Greider — was awarded the Nobel Prize in Physiology or Medicine for her help in discovering "how chromosomes are protected by telomeres." Telomeres protect our DNA ...

Opinions expressed by Forbes Contributors are their own. Telomeres, the protective caps at the ends of our chromosomes, act much like the plastic tips of shoelaces, preventing our DNA from fraying ...

Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of ...

We are entering into an exciting era of genomics where truly complete, high-quality assemblies of human chromosomes are available end-to-end, or from ‘telomere-to-telomere’ (T2T). Recently, the ...

Caption Telomeres are repetitive sequences of DNA capping the ends of chromosomes and protecting them from deterioration or from fusion with neighboring chromosomes. Telomeres shorten ...

In the absence of ZBTB48 (right panel) telomeres become longer whereas the expression of ZBTB48 target genes is strongly reduced. For instance, ZBTB48 KO (knock-out) cells loose the expression of ...