Collagenase clostridium histolyticum is under clinical development by Endo International and currently in Phase III for Unspecified Musculoskeletal Disorders.

Objective: The purpose of the present study was to demonstrate clinical equivalence between the application of collagenase ointment at 24- and 48-hour intervals in the healing of pressure ulcers.

RESULTS MMP-2 (gelatinase A), MMP-3 (stromelysin-1), MMP-11 (stromelysin-3) and MMP-19 were constitutively expressed. MMP-1 (fibroblast type collagenase), MMP-9 (gelatinase B) and MMP-14 (MT1-MMP) ...

Methods for preparing proteinase free of collagenolytic activity have been described 1; but collagenase free of other proteolytic activity has never been obtained.

This study investigates the impact of myenteric neuron-macrophage interactions on postoperative trauma and subsequent ...

A clinical trial involves the study of the safety, efficacy and/or dosage regimen of a therapeutic intervention (such as a drug) in humans selected according to predetermined criteria of ...

Thus, net collagenase activity reflects the relative amounts of activated metalloproteinases and their inhibitors, especially TIMPs. WBC chemoattractant and cytokine release. Increased production ...

Epididymal WAT was minced thoroughly and resuspended in 15 ml digestion solution (7 ml Hanks' solution, 3 ml 7.5% bovine serum albumin (BSA), and 20 mg collagenase type II (Sigma Aldrich, St Louis, ...

This important study implicates Sempharon 4a in both mice and humans as a key suppressor of psoriatic inflammation. The data are in parts incomplete in defining the precise functionally relevant ...

Anaerobic and aerobic bacteria are present in GI lumen whereas only aerobic in the skin. The collagenase activity is greater in the GI tract wound repair especially in the first three days and the ...

During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...

Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India Biomedical Engineering Unit, All India Institute of Medical Sciences, Ansari Nagar, New ...